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Similar results were obtained in a conditioned place preference (CPP) memory test (Fakira et al., 2016) where it was found that RhoA signaling cascade was enhanced during morphine-induced CPP and that bilateral intracranial infusion of the ROCK inhibitor, H1152, completely prevented the formation of CPP

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Process of preparation of transdermal composition of claim 18 wherein penetration enhancer is one or more of Caprylocaproyl polyoxyl-8 glycerides, diethylene glycol monoethyl ether, and Isopropyl myristate